河南大學醫學院官方網站

郭向前

博士、特聘教授、黃河學者
郭向前

一、個人簡介:

郭向前,博士,河南大學基礎醫學院教授、黃河學者、杰出人才特區支持計劃第四層次特聘教授,醫學生物信息學研究所所長,河南省高校科技創新人才。擔任中國老年醫學學會基礎與轉化醫學分會青年委員、河南省抗癌協會腫瘤精準醫學專業委員會常務委員。近幾年,發表SCI論文26篇,論文被引用1000多次,論文期刊總影響因子231。

二、主要研究方向:

主要從事腫瘤分子分型、腫瘤基因標記物篩選、腫瘤基因靶向性治療、分子遺傳學、生物信息學等研究。

三、承擔的研究項目:

1.中國人群平滑肌肉瘤分子分型及靶向性治療手段研究,國家自然科學基金青年項目,81602362,2017-2020,18萬,主持。

2.中國人群平滑肌肉瘤分子亞型及靶向性治療手段探索,河南省科技攻關計劃,162102310391,2015-2017,10萬,主持。

3.食管腺癌精準醫療,河南省青年骨干教師培養計劃,2016GGJS-214,2017-2019,主持。

4.中原地區食管腺癌分子分型及亞型診斷標記物的開發,河南省高校科技創新人才,18HASTIT048,60萬,2018-2019,主持。

5.黃河學者基金,H2016012,河南大學,50萬,2016-2020,主持。

6.杰出人才特區支持計劃第四層次基金,河南大學,200萬,2017-2022,主持。

7.優青培育基金,yqpy20170039,河南大學,10萬,2017-2019,主持。

8.國家自然科學基金培育基金,2015YBZR048,河南大學,1.2萬,2015-2017,主持。

9.新非編碼RNA及其基因的系統發現和“雙色網絡”構建,國家重點基礎研究發展計劃(973計劃),2009CB825401,486萬,2009-2013。參與。

四、已發表論文:

1. An Y, Wang S, Li S, Zhang L, Wang D, Wang H, Zhu S, Zhu W, Li Y, Chen W, Ji S, Guo X. Distinct molecular subtypes of uterine leiomyosarcoma respond differently to chemotherapy treatment. BMC Cancer. 2017 Sep 11;17(1):639. doi: 10.1186/s12885-017-3568-y. (Corresponding Author) (IF= 3.288, SCI二區)

2. Fang, N., T. Gu, Y. Wang, S. Wang, F. Wang, Y. An, W. Wei, W. Zhang, X. Guo, A. Nazarali, S. Ji. Expression of PTEN-long mediated by CRISPR/Cas9 can repress U87 cell proliferation. Journal of Cellular and Molecular Medicine. 2017 Jun 19. doi: 10.1111/jcmm.13236. (IF= 4.499, SCI二區)

3. Peng, L., P. Wang, L. Li, C. Xu, J. Liu, X. Guo, D. He, H. Huang, Z. Cheng. Exomic and Epigenomic Analyses of Monozygotic Twins Discordant for Cryptorchidism. Twin Research and Human Genetics. 2017 Jun 13:1-6. doi: 10.1017/thg.2017.33. (IF= 1.314, SCI四區)

4. Wei, W., X. Ji, X. Guo, S. Ji. Regulatory role of N6-methyladenosine (m6A) methylation in RNA processing and human diseases. Journal of Cellular Biochemistry. 2017 Mar 3. doi: 10.1002/jcb.25967. (IF= 3.085, SCI三區)

5. An, Y., H. Wang, J. Jie, Y. Tang, W. Zhang, S. Ji, X. Guo. Identification of distinct molecular subtypes of uterine carcinosarcoma. Oncotarget. 2017 Feb 2. doi: 10.18632/oncotarget.15032 (Top) (Corresponding Author) (IF= 5.168, SCI一區)

6. Dalerba P.,D.Sahoo, S. Paik, X. Guo, G. Yothers, N. Song, N. Wilcox-Fogel, E. Forgó, P.S. Rajendran, S.P. Miranda, S. Hisamori, J. Hutchison, T. Kalisky, D. Qian, N. Wolmark, G.A. Fisher, M. van de Rijn, M.F. Clarke, CDX2 as a Prognostic Biomarker in Stage II and Stage III Colon Cancer. New England Journal of Medicine, 2016. 374(3):211-22. (Top) (IF= 72.406, SCI一區)

7. Gao S., R. Liu, Zhao, Y., P. Wang, D.G. Ward, G. Wang, X. Guo, G. Gu, W. Niu, T. Zhang, A. Martin, Z. Guo, X. Feng, Y Qi, Y. Ma, Integrative topological analysis of mass spectrometry data reveals molecular features with clinical relevance in esophageal squamous cell carcinoma. Sci Rep., 2016.22(6):21586. (IF= 4.259, SCI二區)

8. Guo, X., S. Su, G. Skogerboe, W. Li, Z. Li, S. Zhang, S. Chen, R. Chen. Differential expression of miRNAs related to caste differentiation in the honey bee, Apis mellifera. Apidologie, 2016. 47:495-508. (IF= 2.196, SCI四區)

9. Guo, X., V.Y. Jo, A. Mills, S. Zhu, C.H. Lee, I. Espinosa, M.R. Nucci, S. Varma, E. Forgo, T. Hastie, S. Anderson, K. Ganjoo, A.H. Beck, R. West, C. Fletcher, and M. van de Rijn, Clinically relevant molecular subtypes in leiomyosarcoma. Clin Cancer Res, 2015. 21(15): p.3501-11. (Top)(IF= 9.619, SCI一區)

10. Guo, X., E. Forgo and M. van de Rijn, Molecular subtyping of leiomyosarcoma with 3' end RNA sequencing. Genomics Data, 2015. 5: 366-367.

11. Demicco, E.G., G.M. Boland, K.J. Brewer Savannah, K. Lusby, E.D. Young, D. Ingram, K.L. Watson, M. Bailey, X. Guo, J.L. Hornick, M. van de Rijn, W.L. Wang, K.E. Torres, D. Lev, and A.J. Lazar, Progressive Loss Of Myogenic Differentiation In Leiomyosarcoma Has Prognostic Value. Histopathology, 2015. 66(5):627-38. (IF= 3.523, SCI二區)

12. Wang, Y., A. Marino-Enriquez, R.R. Bennett, M. Zhu, Y. Shen, G. Eilers, J.C. Lee, J. Henze, B.S. Fletcher, Z. Gu, E.A. Fox, C.R. Antonescu, C.D. Fletcher, X. Guo, C.P. Raut, G.D. Demetri, M. van de Rijn, T. Ordog, L.M. Kunkel, and J.A. Fletcher, Dystrophin is a tumor suppressor in human cancers with myogenic programs. Nat Genet, 2014. 46(6): p. 601-6.(Top) (IF= 27.959, SCI一區)

13. Brunner, A.L.*, J. Li*, X. Guo, R.T. Sweeney, S. Varma, S.X. Zhu, R. Li, R. Tibshirani, and R.B. West, A shared transcriptional program in early breast neoplasias despite genetic and clinical distinctions. Genome Biol, 2014. 15(5): p. R71. (Top) (IF= 11.908, SCI一區)

14. van de Rijn, M., X. Guo, R.T. Sweeney, A.H. Beck, and R.B. West, Molecular Pathological Analysis of Sarcomas Using Paraffin-Embedded Tissue: Current Limitations and Future Possibilities. Histopathology, 2014. 64(1): 163-70. (IF= 3.523, SCI二區)

15. Guo, X., S.X. Zhu, A.L. Brunner, M. van de Rijn, and R.B. West, Next generation sequencing-based expression profiling identifies signatures from benign stromal proliferations that define stromal components of breast cancer. Breast Cancer Res, 2013. 15(6): p. R117. (IF= 6.345, SCI二區)

16. Guo, X., S. Su, G. Skogerboe, S. Dai, W. Li, Z. Li, F. Liu, R. Ni, Y. Guo, S. Chen, S. Zhang, and R. Chen, Recipe for a Busy Bee: MicroRNAs in Honey Bee Caste Determination. PLOS ONE, 2013. 8(12): p. e81661. (IF= 2.806, SCI三區)

17. Newburger, D.E., D. Kashef-Haghighi, Z. Weng, R. Salari, R.T. Sweeney, A.L. Brunner, S.X. Zhu, X. Guo, S. Varma, M.L. Troxell, R.B. West, S. Batzoglou, and A. Sidow, Genome Evolution during Progression to Breast Cancer. Genome Res, 2013. 23(7):1097-108.(Top) (IF= 11.922, SCI一區)

18. Lee, C.H., W.B. Ou, A. Marino-Enriquez, M. Zhu, M. Mayeda, Y. Wang, X. Guo, A.L. Brunner, F. Amant, C.A. French, R.B. West, J.N. McAlpine, C.B. Gilks, M.B. Yaffe, L.M. Prentice, A. McPherson, S.J. Jones, M.A. Marra, S.P. Shah, M. van de Rijn, D.G. Huntsman, P. Dal Cin, M. Debiec-Rychter, M.R. Nucci, and J.A. Fletcher, 14-3-3 fusion oncogenes in high-grade endometrial stromal sarcoma. Proc Natl Acad Sci U S A, 2012. 109(3): p. 929-34.(Top) (IF= 9.661, SCI一區)

19. Brunner, A.L., A.H. Beck, B. Edris, R.T. Sweeney, S.X. Zhu, R. Li, K. Montgomery, S. Varma, T. Gilks, X. Guo, J.W. Foley, D.M. Witten, C.P. Giacomini, R.A. Flynn, J.R. Pollack, R. Tibshirani, H.Y. Chang, M. van de Rijn, and R.B. West, Transcriptional profiling of long non-coding RNAs and novel transcribed regions across a diverse panel of archived human cancers. Genome Biol, 2012. 13(8): p. R75. (Top) (IF= 11.908, SCI一區)

20. Li, M.*, S. Wen*, X. Guo, B. Bai, Z. Gong, X. Liu, Y. Wang, Y. Zhou, X. Chen, L. Liu, and R. Chen, The novel long non-coding RNA CRG regulates Drosophila locomotor behavior. Nucleic Acids Res, 2012. 40(22): p. 11714-27. (Top) (IF= 10.162, SCI一區)

21. Lee, C.H., R.H. Ali, M. Rouzbahman, A. Marino-Enriquez, M. Zhu, X. Guo, A.L. Brunner, S. Chiang, S. Leung, N. Nelnyk, D.G. Huntsman, C. Blake Gilks, T.O. Nielsen, P. Dal Cin, M. van de Rijn, E. Oliva, J.A. Fletcher, and M.R. Nucci, Cyclin D1 as a diagnostic immunomarker for endometrial stromal sarcoma with YWHAE-FAM22 rearrangement. Am J Surg Pathol, 2012. 36(10): p. 1562-70. (IF= 5.363, SCI二區)

22. Wan, L.C.*, F. Wang*, X. Guo, S. Lu, Z. Qiu, Y. Zhao, H. Zhang, and J. Lin, Identification and characterization of small non-coding RNAs from Chinese fir by high throughput sequencing. BMC Plant Biol, 2012. 12: p. 146. (IF= 3.964, SCI三區)

23. Li, D., Y. Wang, K. Zhang, Z. Jiao, X. Zhu, G. Skogerboe, X. Guo, V. Chinnusamy, L. Bi, Y. Huang, S. Dong, R. Chen, and Y. Kan, Experimental RNomics and genomic comparative analysis reveal a large group of species-specific small non-message RNAs in the silkworm Bombyx mori. Nucleic Acids Res, 2011. 39(9): p. 3792-805. (Top) (IF= 10.162, SCI一區)

24. Huang, W., X. Guo, J. Dai, and R. Chen, MicroRNA and lncRNA in Neurodegenerative Diseases. Progress in Biochemistry and Biophysics, 2010. 37(8): p. 8. (IF= 0.341, SCI四區)

25. Shi, B*., X. Guo*, T. Wu*, S. Sheng, J. Wang, G. Skogerbo, X. Zhu, and R. Chen, Genome-scale identification of Caenorhabditis elegans regulatory elements by tiling-array mapping of DNase I hypersensitive sites. BMC Genomics, 2009. 10: p. 92. (*, co-first-author) (IF= 3.729, SCI二區)

26. Tan, Y., B. Zhang, T. Wu, G. Skogerbo, X. Zhu, X. Guo, S. He, and R. Chen, Transcriptional inhibiton of Hoxd4 expression by miRNA-10a in human breast cancer cells. BMC Mol Biol, 2009. 10: p. 12. (IF= 1.939, SCI三區)

五、出版著作:

1. Cheng-Han Lee, Inigo Espinosa, Xiangqian Guo, Matt van de Rijn. Molecular Profiling of sarcomas. Sarcoma Oncology: A Multidisciplinary Approach. People’s Medical Publishing House – USA, 2016 01 Jul. ISBN10:1607950170. (Chapter)

六、講授課程:

醫學生物信息學、醫學統計學上機