河南大學醫學院官方網站

馬遠方

博士、博導、二級教授
馬遠方

  博士、博導、二級教授; 抗體藥物開發技術國家地方聯合工程實驗室主任;中國免疫學會理事、中國免疫學會基礎免疫學專業委員會委員、河南省抗癌協會副理事長、河南省微生物學與免疫學學會副主任委員;國家自然科學獎、國家863計劃、國家自然科學基金評審專家;河南省優秀專家、政府特殊津貼專家。主持完成國家自然科學基金3項、國家863重大專項子課題2項、國家重大新藥創制子項目1項、河南省杰出人才創新基金2項等;以第一完成人獲河南省科技進步二等獎2項、三等獎2項等;獲國家發明專利3項。主編專著6部/副主編2部;發表學術論文200余篇,其中SCI 收錄60余篇。目前主持在研國家自然科學基金1項。

主要研究方向:抗體藥物研發

承擔的研究項目:

1.sDR5-Fc抗體融合蛋白對豬缺血-再灌注心肌的保護作用及機制。81670271,國家自然科學基金,2017.01.01-2020.12.31,57萬,主持人。

1.河南省腫瘤免疫工程創新型科技團隊,30萬,2015.01-2017.12,負責人。

2.熱休克轉錄因子4b(Hsf4b)對晶狀體上皮細胞增生和分化的調控機制,81270985,國家自然科學基金,2013.01-2016.12, 70萬,主持人。

3.抗體研發關鍵技術及產品研發,2012AA02A302,國家863計劃分課題,2012.01-2015.12,22萬,主持人。

4.人源抗體親和力成熟、噬菌體抗體庫、抗體效應功能提高,2011ZX09506-004,國家重大新藥創制科技重大專項子課題,2011.01-2013.12,40萬,主持人。

5.免疫工程創新團隊,2012-2015,260萬。負責人。

6.OCILRP2在T細胞活化中的協同刺激作用及其機制,30972687,國家自然基金,2010.01-2012.12,33萬,主持人。

7.抗死亡受體5基因工程抗體研制及其抗腫瘤作用,WKJ2007-021,衛生部科研項目,2007.1-2009.12,15萬,主持人。

8.人源化及全人抗體構建及優化技術,2006AA02A254,國家863重大專項子課題,2006.12-2010.12,50萬,主持人。

9.抗腫瘤DR5單抗的人源化改造,074200510014,河南省杰出人才創新基金,2007.1-2009.12,50萬,主持人。

10.誘導細胞凋亡的抗DR5單抗與DR5相互作用位點分析,30571697,國家自然基金,2006.1-2008.12,26萬,主持人。

11.死亡受體5單抗在惡性腫瘤診斷治療中的應用研究,0321001800,河南省杰出人才創新基金,2004.1-2006.12,20萬,主持人。

已發表論文:

(*corresponding author)

1.Wang W, Shi Q, Dou S, Li G, Shi X, Jiang X, Wang Z, Yu D, Chen G, Wang R, Xiao H, Hou C, Feng J, Shen B, Ma Y, Han G.Negative regulation of Nod-like receptor protein 3 inflammasome activation by T cell Ig mucin-3 protects against peritonitis.Immunology. 2018 ;153(1):71-83.

2.Liu RM,Sun DN,Jiao YL,Wang P,Zhang J,Wang M,Ma J,Sun M,Gu BL,Chen P,Liu K,Ma H,GaoSG,Ma YF,Qi YJ.Macrophage migration inhibitory factor promotes tumor aggressiveness of esophageal squamous cell carcinoma via activation of Akt and inactivation of GSK3β.Cancer Lett.2018 Jan 1;412:289-296.

3.Ma N, Zhang Y, Liu Q, Wang Z, Liu X, Zhu G, Yu D, Han G, Chen G, Hou C, Wang T,Ma Y,Shen B, Li Y, Xiao H, Wang R.B cell activating factor (BAFF) selects IL-10-B cells over IL-10+B cells during inflammatory responses.Mol Immunol. 2017 May;85:18-26.

4.Li X,Zhang Q, Shi Q, Liu Y, Zhao K, Shen Q, Shi Y, Liu X, Wang C, Li N,Ma Y, Cao X.Demethylase Kdm6a epigenetically promotes IL-6 and IFN-β production in macrophages.J Autoimmun. 2017 Jun;80:85-94.

5.Chen H, Zhang W, Cheng X, Guo L, Xie S, Ma Y, Guo N, Shi M.β2-AR activation induces chemoresistance by modulating p53 acetylation through upregulating Sirt1 in cervical cancer cells.Cancer Sci. 2017 May 12. doi: 10.1111/cas.13275. [Epub ahead of print]

6.Y Li, T Zhou, Y Wang, C Ning, Z Lv, G Han, JC Morris, EN Taylor, R Wang, H Xiao,C Hou,Y Ma,B Shen, J Feng, R Guo, Y Liand G Chen.The protumorigenic potential of FTY720 by promotingextramedullary hematopoiesis and MDSC accumulation.Oncogene (2017), 1–12

7.Yinan Jiang, Xiaoyan Chen, Mengya Fan, Hui Li, Weina Zhu, Xi Chen,Chenghua Cao, Rui Xu, Yaohui Wang,Yuanfang Ma*.TRAIL facilitates cytokine expression and macrophage migrationduring hypoxia/reoxygenation via ER stress-dependent NF- Bpathway.Molecular Immunology.2017;82:123-136.

8.SILEI ZHOU, HUANLING CAO, YAWEI ZHAO, XINYING LI, JIYAN ZHANG, CHUNMEI HOU, YUANFANG MA*and QINGYANG WANG.RACK1 promotes hepatocellular carcinoma cell survival via CBR1 by suppressing TNF-α-induced ROS generation.ONCOLOGY LETTERS 2016;12: 5303-5308.

9.Wang Y, Jiang Y, Zhou J, Song W, Li J, Wang M, Chen J, Xu R, Zhang J, Ma F, Chen YH, Ma Y*.Hepatitis C virus promotes hepatocellular carcinogenesis by targeting TIPE2, a new regulator of DNA damage response.Tumour Biol. 2016 Sep 30.

10.Jiang X, Zhou T, Xiao Y, Yu J, Dou S, Chen G, Wang R, Xiao H, Hou C, Wang W, Shi Q, Feng J, Ma Y, Shen B, Li Y, Han G.Tim-3 promotes tumor-promoting M2 macrophage polarization by binding to STAT1 and suppressing the STAT1-miR-155 signaling axis.Oncoimmunology. 2016 Aug 3;5(9):e1211219

11.Zhou S,Han Q,Wang R,Li X,Wang Q,Wang H,Wang J,Ma Y*. PRDX2 protects hepatocellular carcinoma SMMC-7721 cells from oxidative stress.Oncol Lett. 2016 Sep;12(3):2217-2221.

12.Cui X,Liu H,Li J,Guo K,Han W,Dong Y,Wan S,Wang X,Jia P,Li S,Ma Y,Zhang J,Mu H,Hu Y. Int J Biochem Cell Biol. 2016 Aug 30;79:118-127. Heat shock factor 4 regulates lens epithelial cell homeostasis by working with lysosome and anti-apoptosis pathways.

13.Xu X,Wang H,Liu S,Xing C,Liu Y,Aodengqimuge,Zhou W,Yuan X,Ma Y,Hu M,Hu Y,Zou S,Gu Y,Peng S,Yuan S,Li W,Ma Y,Song L. TP53-dependent autophagy links the ATR-CHEK1 axis activation to proinflammatory VEGFA production in human bronchial epithelial cells exposed to fine particulate matter (PM2.5). Autophagy. 2016 Jul 27:1-17.

14.Deng Q, Chen H, Liu Y, Xiao F, Guo L, Liu D, Cheng X, Zhao M, Wang X, Xie S, Qi S, Yin Z, Gao J, Chen X, Wang J, Guo N, Ma Y*, Shi M.Psychological stress promotes neutrophil infiltration in colon tissue through adrenergic signaling in DSS-induced colitis model.Brain Behav Immun. 2016 Apr 28. pii: S0889-1591(16)30108-8.

15.Lou Q,Hu Y,Ma Y,Dong Z.Heat shock factor 1 induces crystallin-αB to protect against cisplatin nephrotoxicity. Am J Physiol Renal Physiol. 2016 Jul 1;311(1):F94-F102.

16.Lou Q, Ma Y, Qu D.Two-component signal transduction system SaeRS is involved in competence and penicillin susceptibility in Staphylococcus epidermidis.J Basic Microbiol. 2016 ;56(4):358-68.

17.Liu D, Deng Q, Sun L, Wang T, Yang Z, Chen H, Guo L, Liu Y, Ma Y, Guo N, Shi M.A Her2-let-7-β2-AR circuit affects prognosis in patients with Her2-positive breast cancer.BMC Cancer. 2015;15:832.

18.Zhao Y, Wang Q, Qiu G, Zhou S, Jing Z, Wang J, Wang W, Cao J, Han K, Cheng Q, Shen B, Chen Y, Zhang WJ, Ma Y, Zhang J.RACK1 Promotes Autophagy by Enhancing the Atg14L-Beclin 1-Vps34-Vps15 Complex Formation upon Phosphorylation by AMPK.Cell Rep. 2015;13(7):1407-17.

19.Jiang Q, Zhang Z, Li S, Wang Z, Ma Y*, Hu Y.Defective heat shock factor 1 inhibits the growth of fibrosarcoma derived from simian virus 40/T antigen‑transformed MEF cells.Mol Med Rep.2015;12(5):6517-26.

20.Jiang X, Yu J, Shi Q, Xiao Y, Wang W, Chen G, Zhao Z, Wang R, Xiao H, Hou C, Feng J,Ma Y, Shen B, Wang L, Li Y, Han G.Tim-3 promotes intestinal homeostasis in DSS colitis by inhibiting M1 polarization of macrophages.Clin Immunol.2015 Oct; 160(2):328-35.

21.Tan Q, Wang H, Hu Y, Hu M, Li X, Aodeng Q, Ma Y, Wei C, Song L.Src/STAT3-dependent HO-1 induction mediates chemoresistance of breast cancer cells to doxorubicin by promoting autophagy.Cancer Sci. 2015;106(8):1023-32.

22.Ma W, Zhang Y, Mu H, Qing X, Li S, Cui X, Lou Q, Ma Y, Pu H, Hu Y.Glucose regulates heat shock factor 1 transcription activity via mTOR pathway in HCC cell lines.Cell Biol Int. 2015 Nov;39(11):1217-24.

23.Jiang Q, Zhang Z, Li S, Wang Z, Ma Y*, Hu Y.Defective heat shock factor 1 inhibits the growth of fibrosarcoma derived from simian virus 40/T antigen‑transformed MEF cells.Mol Med Rep.2015;12(5):6517-26..

24.Huang H, Song Y, Wu Y, Guo N, Ma Y*, Qian L.Erbin loss promotes cancer cell proliferation through feedback activation of Akt-Skp2-p27 signaling.BBRC.2015 Jul 31;463(3):370-6.

25.Zhao Y, Zhu T, Zhang X, Wang Q, Zhang J, Ji W, Ma Y.*.Splicing factor 2/alternative splicing factor contributes to extracellular-signal regulated kinase activation in hepatocellular carcinoma cells.Mol Med Rep. 2015;12(3):3890-4.

26.Wang WD, Wen Z, Ji W, Ma Y*.RACK1 expression contributes to JNK activity, but JNK activity does not enhance RACK1 expression in hepatocellular carcinoma SMMC-7721 cells.Oncol Lett. 2015;9(6):2767-70.

27.Yang Z, Guo L, Liu D, Sun L, Chen H, Deng Q, Liu Y, Yu M, Ma Y, Guo N, Shi M.Acquisition of resistance to trastuzumab in gastric cancer cells is associated with activation of IL-6/STAT3/Jagged-1/Notch positive feedback loop.Oncotarget. 2015;10;6(7):5072-5087.

28.Liu F,Si Y,Liu G,Li S,Zhang J,Ma Y*.The tetravalent anti-DR5 antibody without cross-linking direct induces apoptosis of cancer cells.Biomed Pharmacother. 2015;70:41-5.

29.Cui X, Xie PP, Jia PP, Lou Q, Dun G, Li S, Liu G, Zhang J, Dong Z, Ma Y, Hu Y.Hsf4 counteracts Hsf1 transcription activities and increases lens epithelial cell survival in vitro.Biochim Biophys Acta.2015;16;1853(3):746-755.

30.Qi YJ, Ward DG, Pang C, Wang QM, Wei W, Ma J, Zhang J, Lou Q, Shimwell NJ, Martin A, Wong N, Chao WX, Wang M, Ma YF*, Johnson PJ. Proteomic profiling of N-linked glycoproteins identifies ConA-binding procathepsin D as a novel serum biomarker for hepatocellular carcinoma. Proteomics. 2014 ;14(2-3):186-95.

31.Yi-Jun Qi, Ming Wang, Rui-Min Liu, Hua Wei, Wei-Xia Chao, Tian Zhang, Qiang Lou, Xiu-Min Li,Jin Ma, Han Zhu, Zhen-Hua Yang, Hai-Qing Liu, Yuan-Fang Ma*. Downregulation of 14-3-3s Correlates with Multistage Carcinogenesis and Poor Prognosis of Esophageal Squamous Cell Carcinoma.PLoS One. 2014;17;9(4):e95386

32.Wang W,Zhang Y,Lv M,Feng J,Peng H,Geng J,Lin Z,Zhou T,Li X,Shen B,Ma Y*,Qiao C.Anti-IGF-1R monoclonal antibody inhibits the carcinogenicity activity of acquired trastuzumab-resistant SKOV3.J Ovarian Res. 2014;7(1):103.

33.Zhao Z,Jiang X,Kang C,Xiao Y,Hou C,Yu J,Wang R,Xiao H,Zhou T,Wen Z,Feng J,Chen G,Ma Y*,Shen B,Li Y,Han G.Blockade of the T cell immunoglobulin and mucin domain protein 3 pathway exacerbates sepsis-induced immune deviation and immunosuppression.Clin Exp Immunol. 2014;178(2):279-91.

34.Qiang Lou, Wei Zhang, Guangchao Liu, Yuanfang Ma*.The C-Type Lectin OCILRP2 Costimulates EL4 T Cell Activation via the DAP12-Raf-MAP Kinase Pathway.PLoS One.2014;20;9(11):e113218.

35.Jiang Q,Zhang Z,Hu Y,Ma Y*.Function of Hsf1 in SV40 T‐antigen‐transformed HEK293T cells.Mol Med Report2014,10: 3139-3144.

36.Lihui Chai, Suxia Wu, Guangchao Liu, Zhanzheng Wang ,Wenzhi Tian,Yuanfang Ma*. OCILRP2 signaling synergizes with LPS to induce the maturation and differentiation of murine dendritic cells.BBRC,2014;18;446(4):836-42.

37.Qiang Lou,Yijun Qi,Yuanfang Ma*,Di Qu.Two-Component Signal Transduction System SaeRS Positively RegulatesStaphylococcus epidermidisGlucose Metabolism.ScientificWorldJournal. 2014 Jan 23.

38.Zhang J,Ma Z,Wang J,Li S,Zhang Y,Wang Y,Wang M,Feng X,Liu X,Liu G,Lou Q,Cui X,Ma Y,Dong Z,Huyz.Regulation of Hsf4b nuclear translocation and transcription activity by phosphorylation at threonine 472.Biochim Biophys Acta.2013,17;1843(3):580-589.

39.Shi M,Yang Z,Hu M,Liu D,Hu Y,Qian L,Zhang W,Chen H,Guo L, Yu M,Song L, Ma Y*,Guo N.Catecholamine-Induced β2-Adrenergic Receptor Activation Mediates Desensitization of Gastric Cancer Cells to Trastuzumab by Upregulating MUC4 Expression.J Immunol.2013 ;190(11):5600-8.

40.Yang X, Jiang X, Chen G, Xiao Y, Geng S, Kang C, Zhou T, Li Y, Guo X, Xiao H, Hou C, Wang R, Lin Z, Li X, Feng J, Ma Y*, Shen B, Li Y, Han G. T Cell Ig Mucin-3 Promotes Homeostasis of Sepsis by Negatively Regulating the TLR Response.J Immunol.2013; 190:2068-79.

41.Guo Y, Wang W, Wang J, Feng J, Wang Q, Jin J, Lv M, Li X, Li Y, Ma Y, Shen B, Zhang J. Receptor for activated C kinase 1 promotes hepatocellular carcinoma growth by enhancing mitogen-activated protein kinase kinase 7 activity. Hepatology.2013;57(1):140-51.

42.Hu YZ, Zahng J, Li S, Wang C, Chu L, Zhang Z, Ma Z, Wang M, Jiang Q, Liu G, Qi Y,Ma Y*.The transcription activity of heat shock factor 4b is regulated by FGF2.Int J Biochem Cell Biol.2013;45(2):317-25.

43.Zhao K, Wang Y, Wang X, Wang Y, Ma Y*.Tagged and untagged TRAIL show different activity against tumor cells. Oncol Lett. 2012;4(6):1301-1304.

44.Qiao C, Hu M, Guo L, Lv M, Lin Z, Geng J, Lang X, Li X, Li Y, Ma Y, Feng J, Shen B. Structural basis of LaDR5, a novel agonistic anti-death receptor 5 (DR5) monoclonal antibody, to inhibit DR5/TRAIL complex formation. BMC Immunol. 2012;13(1):40.

45.Sun H, Zhuang G, Chai L, Wang Z, Johnson D, Ma Y, Chen YH.TIPE2 Controls Innate Immunity to RNA by Targeting the Phosphatidylinositol 3-Kinase-Rac Pathway. J Immunol. 2012;189(6):2768-73.

46.Wei Y, Ma Y(co-first-auther), Zhao Q, Ren Z, Li Y, Hou T, Peng H.New Use for an Old Drug:Inhibiting ABCG2 with Sorafenib.Mol Cancer Ther.2012;11:1693-1702.

47.Xiaoke Gu, Zhiguang Ren, Xiaobo Tang,Hui Peng,Yuanfang Ma,Yisheng Lai,Sixun Peng,Yihua Zhang. Synthesis and biological evaluation of bifendate–chalcone hybrids as a new class of potential P-glycoprotein inhibitors. Bioorg Med Chem.2012;20(8):2540-8.

48.Xiaobo Tang, Xiaoke Gu, Zhiguang Ren,Yuanfang Ma,Yisheng Lai,Hui Peng,Sixun Peng,Yihua Zhang. Synthesis and evaluation of substituted dibenzo[c,e]azepine-5-ones as P-glycoprotein-mediated multidrug resistance reversal agents.Bioorg Med Chem Lett.2012; 22(8):2675-80.

49.Shi M, Zhao M, Hu M, Liu D, Cao H, Qian L, Yang Z, Hu Y, Yu M, Yang S, Ma Y*, Guo N.β2-AR-induced Her2 transactivation mediated by Erbin confers protection from apoptosis in cardiomyocytes. Int J Cardiol. 2013;167:1570-77.

50.Shi M,Du L,Liu D,Qian L,Hu M,Yu M,Yang Z,Zhao M,Chen C,Guo L,Wang L,Song L,Ma Y*,Guo N.Glucocorticoid regulation of a novel HPV E6-p53-miR-145 pathway modulates invasion and therapy resistance of cervical cancer cells.J Pathol.2012;228(2):148-57.

獲得專利:

1.死亡受體5激動性多價抗體及其制備抗腫瘤藥物中的應用,專利號:ZL201210457342.7.發明人:馬遠方,劉峰濤,張軍,李淑蓮,劉廣超。

2.人sDR5蛋白或sDR5-Fc抗體融合蛋白作為心肌梗死治療藥物的應用,專利號:ZL 201210442685.6,發明人:馬遠方,王耀輝,王明麗,張軍,劉廣超,李淑蓮,劉峰濤,胡延忠。申請國際PCT。

3.sDR5-Fc融合蛋白突變體及其應用。申請號:201510510981.9,發明人:馬遠方 王耀輝 張海龍 王明麗 張軍 劉廣超 李淑蓮 頓國慶 胡延忠 祝偉娜。

獲獎情況:

1.TRAIL-R2的表達與腫瘤診斷、治療及預后相關性研究,2008-J-152-R01/01,河南省科技進步獎,二等,2008年11月,第一名。

2.抗死亡受體5單抗在惡性腫瘤診斷治療中的應用,2007-J-147- R01/01,河南省科技進步獎,二等,2007年11月,第一名。

3.支原體試劑盒的研制及應用研究,2001-J-291-R01/07,河南省科技進步獎,三等,2002年5月,第一名。

講授課程:免疫學