河南大學醫學院官方網站

季少平

博士
季少平

教育經歷

1986畢業于第四軍醫大學醫學系

1993畢業于軍事醫學科學院基礎所(三所),獲碩士學位。

1999畢業于第四軍醫大學生物化學與分子生物學系,獲博士學位

工作經歷

1999-2003第四軍醫大學講師,腫瘤生物學國家重點實驗室

2003-2008第四軍醫大學副教授,腫瘤生物學國家重點實驗室

2012河南大學特聘教授,黃河學者,教授

2012河南省生理學會常務理事、神經生物學專業委員會副主委

2012河南省生物化學與分子生物學學會常務理事

1999中國生物化學與分子生物學會會員

獲獎情況

1996軍隊科技進步二等獎,“高熱引起熱損傷的腎上腺素受體機理及抗熱損傷研究”,第五完成人

1999軍隊科技進步一等獎“蛋白酪氨酸激酶Btk在細胞內外與蛋白激酶PKC相互作用的研究”,第三完成人

1999第四軍醫大學教學先進個人,2001第四軍醫大學教學先進個人

2001陜西省優秀博士論文獲得者

科研基金專利情況

1.河南省自然科學基金,長非編碼RNA調控PTEN-long表達分子機制研究,2017.01-2019.12,10萬元,在研,主持。

2.河南省高等學校重點科研項目,17A310004,PTEN假基因PTENP1介導的PTEN-long表達分子機制研究,2017.01-2018.12,5萬元,在研,主持。

3.國家自然科學基金項目,批準號:31371386。PTEN調節ERK5信號影響神經細胞分化的機制研究。2014.1-2017.12,資助7萬元,主持人,國家自然科學基金委立項

4.西部提升計劃,河南大學科技創新團隊資助計劃:2014-2015,資助80萬。

5.河南省科技創新杰出人才基金,批準號:124200510010,PTEN介導的ERK5信號對PC12細胞分化的調節作用. 2012.1-2014.12,資助50萬。主持人,河南省科技廳。

6.河南大學黃河學者啟動基金2012-2016,50+15萬

7.國家自然科學基金項目,批準號:30871239。單泛素化PTEN的核轉位與少突膠質細胞分化抑制。2009.1-2011.12,資助31萬元,主持人,國家自然科學基金委立項。

8.國家自然科學基金項目,批準號:30570676。NDRG2在細胞低氧應激反應中的作用及機制研究。2006.1-2008.12,資助25萬元,主持人,國家自然科學基金委立項,已結題

9.國家重大基礎理論研究發展(973)計劃,“炎癥的細胞信號轉導網絡及其調控機制”。項目編號2002CB513000, 2003-2007年。分題參與者,已結題。

10.國家863課題:“氨抗美”注射液的研制(2001AA215321)。2001-2005年,參與者,已結題

11.GFP-CD19融合蛋白及其在細胞標記方面的應用(CAR-T質控)。申請號:201610354642.0。第一完成人

發表文章

1.Fang N, Gu T, Wang Y, Wang S, Wang F, An Y, Wei W, Zhang W, Guo X, Nazarali AJ,Ji S*.Expression of PTEN-long mediated by CRISPR/Cas9 can repress U87 cell proliferation.J Cell Mol Med. 2017 Jun 19. doi: 10.1111/jcmm.13236. [Epub ahead of print]

2.Wei W, Ji X, Guo X,Ji S*.Regulatory Role of N6 -Methyladenosine(m6 A) Methylationin RNA Processing and Human Diseases.J Cell Biochem. 2017 Mar 3. doi: 10.1002/jcb.25967. [Epub ahead of print])

3.Wei W, Wang H,Ji S*.Paradoxes of the EphB1 receptor in malignant brain tumors. Cancer Cell Int. 2017 Feb 8;17:21. doi: 10.1186/s12935-017-0384-z.

4.Thangaraj MP, Furber KL, Gan JK,Ji S, Sobchishin L, Doucette JR, Nazarali AJ. RNA binding protein Quaking stabilizes Sirt2 mRNA during oligodendroglial differentiation. J Biol Chem. 2017 Feb 10. pii: jbc.M117.775544. doi: 10.1074/jbc.M117.775544.

5.Di Y, Ji S, Wolf P, Krol ES, Alcorn J. Enterolactone glucuronide and β-glucuronidase in antibody directed enzyme prodrug therapy for targeted prostate cancer cell treatment. AAPS PharmSciTech. 2017 Jan 23. doi: 10.1208/s12249-017-0721-5.

6.Yang An, Haojie Wang, Jingyao Jie, Yitai Tang, Weijuan Zhang,Shaoping Ji*, Xiangqian Guo*. Identification of distinctmolecular subtypes of uterine carcinosarcoma Oncotarget,Oncotarget.2017 Feb 2. doi: 10.18632/oncotarget.15032. [Epub ahead of print]

7.Yang An,Kendra L.Furber,Shaopig Ji*. Pseudogenes Regulate Parental Gene Expression via ceRNA Network. Journal of Cellular and Molecular Medicine. 2016 Aug 25. doi: 10.1111/jcmm.12952. [Epub ahead of print]

8.Shaoping Ji, Doucette JR, Nazarali AJ.Protocols for Cloning, Expression, and Functional Analysis of Sirtuin2(SIRT2).Methods Mol Biol. 2016;1436:189-99. doi: 10.1007/978-1-4939-3667-0_13.

9.Fengling Wang, Adil J. Nazarali,Shaoping Ji*. Circular RNAs as potential biomarkers for cancer diagnosis and therapy. American Journal of Cancer Research. 2016, 6(6):1167-1176

10.Wenqiang Wei, Hongju Wang, Xiaoya Li, Na Fang, Shili Yang, Hongyan Liu, Xiaonan Kang, Xiulian Sun, andShaoping Ji*, Cloning and Characterization of Sf9 Cell Lamin and the Lamin Conformational Changes during Autographa californica multiple nucleopolyhedrovirus Infection. Viruses 2016, 8, 126; doi: 10.3390/v8050126

11.Fang N, Zhong N, Yang Y, Guo Y,Ji S*.Data of expression and purification of recombinant Taq DNA polymerase.Data Brief. 2016 Aug 20; 9:81-4. doi: 10.1016/j.dib.2016.08.032. eCollection 2016 Dec.

12.Yamei Hu, Yang An, Na Fang, Yanzhang Li, Haiying Jin, Adil Nazarali,Shaoping Ji*.The Optimization of Soluble PTEN Expression in Escherichia coli.The Open Biochemistry Journal, 2015, 9: 42-48

13.Wang J, Sun Z, Shen J, Wu D, Liu F, Yang R,Ji S, Ji A, Li Y.Octreotide Protects the Mouse Retina against Ischemic Reperfusion Injury through Regulation of Antioxidation and Activation of NF-κB.Oxid Med Cell Longev. 2015; 970156.

14.Wu D, Zheng N, Qi K, Cheng H, Sun Z, Gao B, Zhang Y, Pang W, Huangfu C,Ji S, Xue M, Ji A, Li Y.xogenous hydrogen sulfide mitigates the fatty liver in obese mice through improving lipid metabolism and antioxidant potential.Med Gas Res. 2015;5(1):1.

15.Wang J, Wang S, Li M, Wu D, Liu F, Yang R,Ji S, Ji A, Li Y.The Neuropilin-1 Inhibitor, ATWLPPR Peptide, Prevents Experimental Diabetes-Induced Retinal Injury by Preserving Vascular Integrity and Decreasing Oxidative Stress.PLoS One. 2015 Nov 10;10(11): e0142571.

16.Yinguo Bai, Na Fang, Tingxun Gu, Yuhua Kang, Jiang Wu, Desheng Yang, Hui Zhang, Zhimin Suo andShaoping Ji*.HOXA11 gene is hypermethylation and aberrant expression in gastric cancer.Cancer Cell International 2014 Aug 19;14:79

17.Wang T, Jia L, Yang G,Ji S, Yao L, Zhang B.Identification of Juxtanodin promoter and its transcriptional regulation during the ATRA-induced differentiation of C6 cells.Mol Cell Biochem. 2011 Apr;350(1-2):177-83.

18.Shaoping Ji, Ronald Doucette, and Adil J. Nazarali. Sirt2 is a novel in vivo downstream target of Nkx2.2 and enhances oligodendroglial cell differentiation.J Mol Cell Biol.2011;3(6):351-9

19.Jia L,Ji S(co-first author), Maillet JC, Zhang X.PTEN suppression promotes neurite development exclusively in differentiating PC12 cells via PI3-kinase and MAP kinase signaling.J Cell Biochem.2010; 111(6):1390-400.

20.Dang N, Hu J, Liu X, Li X,Ji S, Zhang W, Su J, Lu F, Yang A, Han H, Han W, Jin B, Yao L.CD167 acts as a novel costimulatory receptor in T-cell activation.J Immunother. 2009 Oct;32(8):773-84.

21.Wang L, Liu N, Yao L, Li F, Zhang J, Deng Y, Liu J,Ji S, Yang A, Han H, Zhang Y, Zhang J, Han W, Liu X (2008). NDRG2 is a new HIF-1 target gene necessary for hypoxia-induced apoptosis in A549 cells.Cell. Physiol. Biochem. 21:239-250.

22.Liu N,Wang LF,Li X, Yang Q,Liu XP,Zhang J, Zhang J, Wu YS,Ji SP, Zhang YQ, Yang AG, Han H and Yao LB. N-Myc downstream-regulated gene 2 is involved in p53-mediated apoptosis.Nucleic Acids Research, 2008, 1–15

23. Ji, S, Zhang, Y, Van Cleemput, J, Jiang W, Wan Q, Backstrom JR, Zhang X (2006). Disruption of protein-protein coupling between PTEN and serotonin 5-HT2C receptor suppresses marijuana-induced rewarding effects.Nature Medicine. 12:324-329.

24. Zhang J, Li F, Liu X, Shen L, Liu J, Su J, Zhang W, Deng Y, Wang L, Liu N, Han W, Zhang J,Ji S, Yang A, Han H, Yao L (2006). The repression of human differentiation-related gene NDRG2 expression by Myc via Miz-1-dependent interaction with the NDRG2 core promoter.J Biol Chem. 281:39159-39168.

25. Jiang W, Zhang Y, Xiao L, Van Cleemput J,Ji SP, Bai G, Zhang X (2005). Cannabinoids promote embryonic and adult hippocampus neurogenesis and produce anxiolytic- and antidepressant-like effects.J Clin. Invest. 115(11): 3104-3116.

26. Jiang W, Van Cleemput J, Sheerin AH,Ji S, Zhang Y, Saucier DM, Corcoran ME, Zhang, X (2005) Involvement of Extracellular Regulated Kinase and p38 Kinase in Hippocampal Seizure Tolerance.J Neurosci Res. 81:581-588.

27.Zhang J,Wang JC,Han YH,Wang LF,Ji SP,Liu SX,Liu XP,Yao LB. (2005). High expression of bcl-x(L) in K562 cells and its role in the low sensitivity of K562 to realgar-induced apoptosis.Acta Haematol. 113:247-254.

28. Ji S, Liu X, Li S, Shen L, Li F, Wang J, Han J, Yao L.(2003). PH domain of G protein-coupled receptor kinase-2 binds to protein kinase C (PKC) and negatively regulates activity of PKC kinase.Front Biosci-landmrk. 8:a34-39.

29. Deng Y, Yao L, Chau L, Ng SS, Peng Y, Liu X, Au WS, Wang J, Li F,Ji S, Han H, Nie X, Li Q, Kung HF, Leung SY, Lin MC. (2003). N-Myc downstream-regulated gene 2 (NDRG2) inhibits glioblastoma cell proliferation.Int J Cancer.106: 342-347.

30. Wang J, Lu H, Liu X, Deng Y, Sun T, Li F,Ji S, Nie X, Yao L (2002).Functional analysis of discoidin domain receptor 2 in synovial fibroblasts in rheumatoid arthritis.J Autoimmun. 19:161-168.

31. Li F, Yang Y, Liu X He P,JiS, Wang J, Han J, Chen N, Yao, L (2000). Human Glioma Cell BT325 Expresses a Proteinase That Converts Human Plasminogen to Kringle 1-5-Containing Fragments.Biochem. Biophys. Res. Commun. 278: 821-825.

32.JiSP,Yao LB,Bai YJ,Wang JC,Liu XP,Su CZ. Binding of Insulin Receptor Substrate 1 PH Domain to Protein Kinase C.Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai).1999;31(4):400-404.