河南大學醫學院官方網站

吉愛玲

博士、教授
吉愛玲

  女,1965年生。博士、教授、教研室主任。研究方向:人類生物學。專注細胞生物學,神經生物學。

全日制教育(畢業時間、院校、系及專業) 

1983.9-1987.7 河南師范大學 生物系 生物學專業 學士學位 

1987.9-1990.7 北京師范大學 細胞生物學專業 碩士學位 

獲得獎懲 

教學成果 

科研業績 國際會議摘要 

1. A. Ji, J. M. Wroblewski, N. R. Webb, D. R. van der Westhuyzen. PLTP Acts in Concert with 

SAA to Reduce Plasma HDL Levels in Miceand Modulates Nascent HDL Formation in 

Hepatocytes Arteriosclerosis, thrombosis, and Vascular Biology Annual Conference in Chicago, 

Illinois, USA on April 28-30, 2012 

2. J. Meyer, A. Ji, L. Cai, D. R. van der Westhuyzen. Novel Mechanism of Low-Density 

Lipoprotein--Derived Cholesteryl Ester Uptake and Hydrolysis During Macrophage Foam Cell 

Formation Arteriosclerosis, thrombosis, and Vascular Biology Annual Conference in Chicago, 

Illinois, USA on April 28-30, 2012 

3. L. Cai, Z. Wang, J. Meyer, A. Ji, X. Wang, D. R. van der Westhuyzen. SR-BI in Macrophages 

Modulate Inflammatory Response to LPS Arteriosclerosis, thrombosis, and Vascular Biology 

Annual Conference in Chicago, Illinois, USA on April 28-30, 2011 

4. J. Meyer, A. Ji, L. Cai, D. R. van der Westhuyzen. Low-Density Lipoprotein Cholesteryl Esters 

Are Taken Up Selectively by Macrophages into a Reversible Pool Arteriosclerosis, thrombosis, 

and Vascular Biology Annual Conference in Chicago, Illinois, USA on April 28-30, 2011 

5. A. Ji, J. M. Wroblewski, A. Jahangiri, M. C. De Beer, F. C. De Beer, D. R. van der Westhuyzen. 

Serum Amyloid A and Endothelial Lipase Decrease ABCA1-dependent HDL Formation by 

hepatocytes 6th IAS-Sponsored Workshop on High Density Lipoproteins in Whistler, British 

Columbia, Canada on May 17-20, 2010 

6. A. Jahangiri, D. R. van der Westhuyzen, M. C. De Beer, J. M. Wroblewski, V. J. Noffsinger, A. 

Ji, F. C. De Beer. HDL Remodeling by Serum Amyloid A and Cholesteryl Ester Transfer Protein 

in Vivo Enhances ABCA1-dependent Cholesterol Efflux 6th IAS-Sponsored Workshop on High 

Density Lipoproteins in Whistler, British Columbia, Canada on May 17-20, 2010 

7. A. Ji, L. Cai, M. C. De Beer, J. M. Wroblewski, X. Wang, Z. Wang, D. R. van der Westhuyzen. 

HDL Formation by Hepatocytes: Role of ABC Transporters A1, G1, andScavenger Receptor B-I 

2010 Arteriosclerosis, thrombosis, and Vascular Biology Annual Conference in San Francisco, 

California, USA

科研業績 

8. 

J. M. Wroblewski, A. Ji, A. Jahangiri, M. C. De Beer, V. J. Noffsinger, D. R. van der 

Westhuyzen, F. C. De Beer. Serum Amyloid A and Endothelial Lipase Decrease HDL Formation 

in Mice Both in Vivo and in Vitro 2010 Arteriosclerosis, thrombosis, and Vascular Biology 

Annual Conference in San Francisco, California, USA 

9. A. Akinmusire, L. Cai, A. Ji, D. R. van der Westhuyzen. Uptake and Intracellular Trafficking of 

HDL Apolipoproteins 2010 Arteriosclerosis, thrombosis, and Vascular Biology Annual 

Conferencein San Francisco, California, USA 

10. L. Cai, Z. Wang, A. Ji, J. Meyer, X. Wang, E. Eckhardt, D. R. van der Westhuyzen. Scavenger 

Receptor CD36 Influences Adipocyte Tissue Function 2010 Arteriosclerosis, thrombosis, and 

Vascular Biology Annual Conference in San Francisco, California, USA 

11. M. C. De Beer, J. M. Wroblewski, A. Jahangiri, A. Ji, D. R. van der Westhuyzen, F. C. De Beer, 

N. R. Webb. Cellular Cholesterol Efflux During the Acute Phase 2010 Arteriosclerosis, 

thrombosis, and Vascular Biology Annual Conference in San Francisco, California, USA 

12. A. Ji, L. Cai, M. C. De Beer, X. Wang, Z. Wang, D. R. van der Westhuyzen. High Density 

Lipoprotein remodeling by Scavenger Receptor Class B Type I  and Cholesteryl Ester Transfer 

Protein and the Effects on Cholesterol Transport 2009 Arteriosclerosis, thrombosis, and Vascular 

Biology Annual Conference in Washington, DC, USA 

13. A. Ji 

, D. R. van der Westhuyzen. SR-BI regulation and function in bone marrow macrophages 

Gill Heart Institute Cardiovascular Research Day 2008, Lexsington, KY, USA 

14. L. Cai, A. Ji

, Y. Li, X. Wang, T. Liu, J. Meyer, D. R. van der Westhuyzen. The role of HDL 

receptor SR-BI and LDL receptor in adrenal steroid hormone synthesis Gill Heart Institute 

Cardiovascular Research Day 2008, Lexington, KY, USA 

15. A. Ji

, L. Cai, A. Akinmusire, X. Wang, Z. Wang, D. R. van der Westhuyzen. SR-BI dependent 

cholesterol efflux in macrophages. 2008 South East Lipid Research Conference, Georgia, USA 

16. A. Ji

, L. Cai, X. Wang, Y. Li, A. Akinmusire, D. R. van der Westhuyzen. Aggregated LDL 

downregulates macrophage SR-BI expression. Program No. P151. 2008 Arteriosclerosis, 

thrombosis, and Vascular Biology Annual Conference in Atlanta, Georgia, USA 

17. L. Cai, A. Ji

, Y. Li, S. Shetty, D. R. van der Westhuyzen. The role of HDL receptor SR-BI and 

LDL receptor in adrenal steroid hormone synthesis. Program No. P142. 2008 Arteriosclerosis, 

thrombosis, and Vascular Biology Annual Conference in Atlanta, Georgia, USA 

18. M. C. De Beer, L. Cai, A. Ji

, F. C. De Beer, D. R. van der Westhuyzen. SAA blocks modified 

LDL uptake and promotes cellular cholesterol efflux in a CD36-specific manner. PO4-105 76 th 

Congress of the European Atherosclerosis SocietyJune 10-13, 2007, Helsinki, Finland 

19. L. Cai, M. C. De Beer, A. Ji

, F. C. De Beer, D. R. van der Westhuyzen. SAA promotes CD36 

mediated cellular cholesterol efflux Gill Heart Institute Cardiovascular Research Day 2006, 

Lexington, KY, USA 

20. A. Ji

, Y. Li, M. Peter, E. Weihe, M.K. Schafer. Cell-specific expression of calcitonin receptor 

isoforms in hypothalamic neurons regulating feeding behaviour. Program No. 49.17. 2003 

Abstract Viewer/Itinerary Planner.Washington, DC, USA: Society for Neuroscience, 2003. 

Online. 

21. Y. Li; A. Ji

; F. Bender; M. Bette; E. Weihe; M.K.-H. Schafer (2001) Neuronal and 

non-neuronal expression of TNF receptors in rat dorsal root ganglion: effects of LPS. Soc 

Neurosci Abstr 27:52.2.

科研業績 

22. F.L.P. Bender, M. Mederos y Schnitzler, Y. Li, A. Ji

, E. Weihe, T. Gudermann, M.K. Schafer. 

Expression and functional characterization of the vanilloid receptor-like trp channel vrl-1 in the 

primary sensory cell line f-11.  program no. 48.23. 2002 abstract viewer/itinerary planner. 

Washington, DC, USA: Society for Neuroscience, 2002. Online. 

23. Y. Li, A. Ji

, M.K. Schafer. Toll-like receptor 4 is expressed by peptidergic presumed nociceptive 

neurons in rat dorsal root ganglion Program No. 46.19. 2002 Abstract Viewer/Itinerary Planner. 

Washington, DC, USA: Society for Neuroscience, 2002. Online. 

學術論文 

1. Ailing Ji

, Joanne M. Wroblewski, Nancy R. Webb and Deneys R. van der WesthuyzenImpact of 

Phospholipid Transfer Protein on Nascent High-Density Lipoprotein Formation and Remodeling 

Arterioscler Thromb Vasc Biol. 2014;34:1910-1916. (SCI, IF 6.338) 

2. Jason M. Meyer, Ailing Ji

,  Lei Cai , and Deneys R. van der WesthuyzenMinimally oxidized 

LDL inhibits macrophage selective cholesteryl ester uptake and native LDL-induced foam cell 

formationJ. Lipid Res . 2014. 55: 1648–1656. (并列第一作者) 

3. Maria C. De Beer, Joanne M. Wroblewski, Victoria P. Noffsinger, Debra L. Rateri, Deborah A. 

Howatt, Anju Balakrishnan, Ailing Ji

, Preetha Shridas, Joel C. Thompson, Deneys R. van der 

Westhuyzen, Lisa R. Tannock, Alan Daugherty, Nancy R. Webb and Frederick C. De Beer 

Deficiency of Endogenous Acute Phase Serum Amyloid A Does Not Affect Atherosclerotic 

Lesions in Apolipoprotein E-Deficient MiceArterioscler Thromb Vasc Biol. 

2014;34:255-261(SCI, IF 6.338) 

4. Maria C. de Beer, Joanne M. Wroblewski, Victoria P. Noffsinger, Ailing Ji, 

Jason M. Meyer, 

Deneys R. van der Westhuyzen, Frederick C. de Beer, and Nancy R. Webb The Impairment of 

Macrophage-to-Feces Reverse Cholesterol Transport during Inflammation Does Not Depend on 

Serum Amyloid AJ Lipids. 2013; 2013: 283486 

5. Ji A, 

Wroblewski JM, Cai L, de Beer MC

, Webb NR, van der Westhuyzen DR. Nascent HDL 

formation in hepatocytes and role of ABCA1, ABCG1 and SR-BIJ Lipid Research 2012, 

53(3):446-55.(SCI, IF 5.559) 

6. Meyer JM, Ji A

, Cai L, van der Westhuyzen DR. High-capacity selective uptake of cholesteryl 

ester from native LDL during macrophage foam cell formationJ Lipid Research 2012, 

Oct;53(10):2081-91.(SCI, IF 5.559) 

7. Cai L, Wang Z, Ji A

, Meyer JM, van der Westhuyzen DR. Scavenger Receptor CD36 Expression 

Contributes to Adipose Tissue Inflammation and Cell Death in Diet-Induced Obesity. PLoS ONE 

2012, 7(5): e36785. doi:10.1371/journal.pone.0036785. (SCI, IF 4.411) 

8. L. Cai, Z. Wang, J. Meyer, A. Ji

, D. R. van der Westhuyzen. Macrophage SR-BI regulates 

LPS-induced pro-inflammatory signaling in mice and isolated macrophages J Lipid Research 

2012, Aug;53(8):1472-81. (SCI, IF 5.559) 

9. A. Ji, J. Meyer, L. Cai, A. Akinmusire, M. C. De Beer, N. R. Webb, D. R. van der 

Westhuyzen. Scavenger Receptor SR-BI in Macrophage Lipid Metabolism Atherosclerosis 2011, 

217(1):106-12. (SCI, IF 3.794) 

10. Wroblewski JM, Jahangiri A, Ji A, de Beer FC, van der Westhuyzen DR, Webb NR. Nascent 

HDL formation by hepatocytes is reducedby the concerted action of serum amyloid A and 

endothelial lipase. J Lipid Research 2011, 52(12):2255-61. (SCI, IF 5.559) 

11. De Beer MC, Ji A, Jahangiri A, Vaughan AM, De Beer FC, Van der Westhuyzen DR, Webb 

NR. ATP binding cassette G1-dependent cholesterol efflux during inflammation. J Lipid Research 

2011, 52(2):345-53. (SCI, IF 5.559)

科研 

業績 13. De Beer MC, Webb NR, Wroblewski JM, Noffsinger VP, Rateri DL, Ji A, Van Der 

Westhuyzen DR, De Beer FC. Impact of serum amyloid A on high density lipoprotein 

composition and levels. J Lipid Research 2010, 51(11):3117-25. (SCI, IF 5.559) 

14. 吉愛玲

, 封青川,畢彩霞,徐存栓 (2001)HSP 70 單克隆抗體的制備. 動物學報,47(專刊): 

247-249 

15. 徐存栓, 李永輝,段瑞峰,盧愛靈,夏民,吉愛玲 

(2001) 短間隔連續部分肝切除對大鼠 

生存和肝組織結構的影響. 動物學報 47(6), 659-665. 

16. 李效宇, 夏民, 李莉, 卜艷珍, 吉愛玲

, 姬生棟, 徐存栓 (2000) 金魚不同組織器官及胚胎發 

育不同時期蛋白水解酶的種類和活性變化. 水生生物學報 24 (2), 128-136. 

17. 胡軼紅, 吉愛玲

, 徐存栓 (2000) 大鼠八種器官的蛋白質圖譜分析. 河南科學 18(1), 59-62. 

18. 姬生棟,李金亭,吉愛玲

, 李吉學,王丹,徐存栓 (2000) 小麥生育前期 POD 同工酶的 

動態變化 (2000) 廣西植物 20(4), 361-366. 

19. 吉愛玲

, 李彥章, 向華, 伍雁, 封青川, 徐存栓 (1999) 獼猴消化系統各器官蛋白水解酶種 

類和性質研究. 解剖學報 30(3), 230-236. 

20. 李彥章, 吉愛玲

., 夏民, 姬生棟,伍雁, 楊春玲, 封青川 徐存栓 (1999) 獼猴神經系統各器 

官蛋白水解酶種類和性質研究. 動物學雜志 33(6), 31-34. 

21. 吉愛玲

, 胡軼紅, 封青川, 李效陽, 盧愛玲, 徐存拴 (1999) 大白鼠熱休克反應中HSP70 的 

表達動態分析. 中國動物科學研究 823-826 中國動物學會編, 中國林業出版社. 

22. 吉愛玲

, 楊保勝, 向華, 李效陽, 孫璐, 徐存拴 (1999) 復方腫瘤血管生成抑制因子口服液 

對小鼠免疫功能的影響. 河南師范大學學報 (自然科學版) 27(1), 64-68. 

23. 徐存拴, 李臘月, 吉愛玲

, 向華, 石金保, 李全富, 楊保勝 (1999) 復方腫瘤血管生成抑制 

因子口服液與化療藥物合用對小鼠 Ehrlich腹水癌的抑制作用研究. 河南師范大學學報 (自然科學 

版) 27(1), 60-63. 

24. 姬生棟, 夏民, 吉愛玲

, 李吉學, 王丹, 李庚午 (1999) 不同基因型小麥葉片氣孔超微結構觀 

察 中國醫學物理學雜志 16(5), 98-99. 

25. 姬生棟, 吉愛玲

, 夏民, 李吉學, 李庚午 (1999) 三種春化類型小麥葉片的掃描電鏡觀察 中 

國醫學物理學雜志 16(5), 100-102. 

26. 徐存栓, 吉愛玲

, 夏民, 常蘊華, 伍雁, 趙緒永 (1998) 用復性電泳技術研究溶酶體蛋白水 

解酶的性質和活性. 河南科學 16(2), 185-192. 

27. 吉愛玲, 趙曉進, 李彥章, 伍雁, 楊春玲, 封青川, 徐存栓 (1998) 獼猴生殖, 泌尿, 免疫系 

統各器官蛋白水解酶種類和性質. 解剖學報 29(2), 195-199. 

28. 徐存栓, 吉愛玲, 夏民, 李彥章, 向華. (1998). C6大白鼠神經膠質瘤細胞HSP68 的修飾和降 

解分析. 生物化學與生物物理學報 30(2),179-184. 

29. Guangchang Pang, Dongxu Zhao, Xinlin Yang, Guangwen Chen, Ailing Ji (1998) A New 

Technique of Micro-protein-electrophoresis and Ultrasensitive Staining. Developmental and Reproductive 

Biology 7(1), 81-89. 

30. 吉愛玲, 趙曉進, 李彥章, 伍雁, 楊春玲, 封青川, 徐存栓 (1998) 獼猴生殖, 泌尿, 免疫系 

統各器官蛋白水解酶種類和性質. 解剖學報 29(2), 195-199. 

31. 徐存栓, 吉愛玲, 夏民, 李彥章, 向華. (1998). C6大白鼠神經膠質瘤細胞HSP68 的修飾和降 

解分析. 生物化學與生物物理學報 30(2),179-184. 

32. Guangchang Pang, Dongxu Zhao, Xinlin Yang, Guangwen Chen, Ailing Ji (1998) A New 

Technique of Micro-protein-electrophoresis and Ultrasensitive Staining. Developmental and 

Reproductive Biology 7(1), 81-89 

33. 姬生棟, 夏民, 吉愛玲

, 胡軼紅, 王丹, 徐存栓 (1997) 不同基因型小麥籽粒生育期蛋白質的 

動態變化. 河南師范大學學報 25(4), 75-78 

34. 吉愛玲

, 李華, 楊曉紅, 柳惠圖 (1992) 6m2 細胞轉化與肌醇磷脂代謝相關性研究. 生物化 

學雜志 8(4), 390-394.

科研 

業績 GenBank Accession Number 

1. A. Ji

, Li,Y., Bender,F.L.P. and Schafer,M.K.H. (2003) F-11 rat/mouse fusion cell line TRPV2 

protein mRNA, complete cds. GenBank AY487844 

2. Y. Li, A. Ji

, M. K. Schafer (2002) Rattus norvegicus TNFR2 mRNA, transcript variant 1, 

AF498039; transcript variant 2, AY191268; transcript variant 3, AY191269 

3. Y. Li, A. Ji

, M. K. Schafer (2002) Rattus norvegicus toll likereceptor 2 mRNA, transcript variant 

1, AY151255; transcript variant 2, AY151256 

4. Y. Li, A. Ji

, M. K. Schafer (2002) Rattus norvegicus toll like receptor 9 mRNA, complete cds. 

GenBank AY191271. 

5. Y. Li, A. Ji

, M. K. Schafer (2002) Rattus norvegicus myeloid differentiation primary response 

gene 88 (MyD88), complete cds. GenBank AY191270 

6. Y. Li, A. Ji

, M. K. Schafer (2001) Rattus norvegicus CGRP-receptor component protein mRNA, 

complete cds. GenBank AF440799. 

Award 

2010 HDL Workshop Travel Awards for Young Investigators 

6 th IAS-Sponsored Workshop on High Density Lipoproteins in Whistler, British Columbia, Canada 

on May 17-20, 2010 

高等院校教材 

現代細胞生物學技術, 副主編,青島海洋大學出版社 1995 年 

現代細胞遺傳學, 編委,河南科技出版社 1994 年 

參加科研項目 

1. National Institutes of Health (NIH) Program Project Grant PO1 HL086670 to D. R. van der 

Westhuyzen (PI) 04/01/07-03/30/12, total $ 5,065,000 USA 

HDL Function and Metabolism During Inflammation 

2. National Institutes of Health (NIH) R01 HL063763 to D.R. van der Westhuyzen (PI) 08/01/05 – 

07/31/09, total $1,125,000 USA 

SR-BI and SR-BII Recycling and Selective Lipid Uptake 

3. Bundesministerium für Bildung und Forschung (BMBF) 01GS01118,德國教育科技部項目, 

2000-2004,100萬歐元 

4. 熱休克誘導的 65KDaATP 結合蛋白酶基因的分離, 國家自然科學基金 39670372, 1996-1999, 

第二完成人 

5. 蛋白酶體在熱休克反應中的作用,河南省科委 964021900, 0.5 萬元,1996-1998,主持人 

6. 基因工程人 D 型干擾素生產工藝研究,河南省教育廳 96180013,0.5 萬元, 1996-1999, 

第三完成人 

7. 肝再生過程中蛋白酶與 HSP 動態變化及肝功能調節中的作用, 河南省教育廳 96180017, 0.5 

萬元, 1996-1999,第三完成人 

8. 熱休克蛋白調節小麥生長發育的分子機制研究,河南省科委 974013100,0.5 萬元, 

1997-1999,第三完成人 

9. 麥田雜草蛋白水解酶譜分析及新型除草劑研究,98180012,1.5 萬元, 1998-2000,第四完 

成人 

科學技術成果鑒定 

復方腫瘤血管生成抑制因子口服液抗腫瘤作用研究,河南省科委, 豫科鑒委字 (1998) 第108 號,第五完成人。